Flights from Des Moines to Knoxville (DSM → TYS)

DSM
Des Moines
Des Moines International, USA
TYS
Knoxville
Mc Ghee Tyson, USA
Loading map...
No direct flights found. Here are the 20 fastest 1-stop options.
viaNashville(BNA)
DSM→BNA+1h 30mBNA→TYS
2h 47m
viaChicago(MDW)
DSM→MDW+1h 30mMDW→TYS
2h 57m
viaChicago(ORD)
DSM→ORD+1h 30mORD→TYS
2h 58m
viaAtlanta(ATL)
DSM→ATL+1h 30mATL→TYS
3h 11m
viaDetroit(DTW)
DSM→DTW+1h 30mDTW→TYS
3h 20m
viaCharlotte(CLT)
DSM→CLT+1h 30mCLT→TYS
3h 22m
viaMinneapolis(MSP)
DSM→MSP+1h 30mMSP→TYS
3h 26m
viaFort Walton Beach(VPS)
DSM→VPS+1h 30mVPS→TYS
3h 53m
viaGulf Shores(GUF)
DSM→GUF+1h 30mGUF→TYS
3h 56m
viaWashington(DCA)
DSM→DCA+1h 30mDCA→TYS
4h 1m
viaDallas(DFW)
DSM→DFW+1h 30mDFW→TYS
4h 8m
viaJacksonville(JAX)
DSM→JAX+1h 30mJAX→TYS
4h 9m
viaPhiladelphia(PHL)
DSM→PHL+1h 30mPHL→TYS
4h 23m
viaHouston(IAH)
DSM→IAH+1h 30mIAH→TYS
4h 29m
viaHouston(HOU)
DSM→HOU+1h 30mHOU→TYS
4h 33m
viaOrlando(SFB)
DSM→SFB+1h 30mSFB→TYS
4h 36m
viaNew York(EWR)
DSM→EWR+1h 30mEWR→TYS
4h 37m
viaNew York(LGA)
DSM→LGA+1h 30mLGA→TYS
4h 40m
viaSaint Petersburg(PIE)
DSM→PIE+1h 30mPIE→TYS
4h 41m
viaAustin(AUS)
DSM→AUS+1h 30mAUS→TYS
4h 43m
Search all options on Kiwi.com → Total times include an estimated 90-minute layover. Actual times vary by airline and connection.

Frequently asked questions

Are there direct flights from Des Moines to Knoxville? Currently, there are no direct flights from DSM to TYS. You may need to connect through another airport.

Related guides for this route

Sibling pages from across Flightmaps — fares, visa rules, country aggregations, and per-airline routes for Des Moines → Knoxville.

Cheap flights from Des Moines to Knoxville Cheapest month to fly to Knoxville Flights from USA Flights to USA Visa-free with USA passport All airports in USA

Try a nearby airport to Des Moines

Flights to Knoxville (TYS) from other airports within 350 km of Des Moines. Often unlocks cheaper fares or better times.

CID → TYS 166 km from DSM Cedar Rapids → Knoxville USA · 20 destinations OMA → TYS 190 km from DSM Omaha → Knoxville USA · 37 destinations MLI → TYS 262 km from DSM Moline → Knoxville USA · 11 destinations MCI → TYS 265 km from DSM Kansas City → Knoxville USA · 60 destinations LNK → TYS 271 km from DSM Lincoln → Knoxville USA · 9 destinations

Or try a nearby airport to Knoxville

Flights from Des Moines (DSM) to other airports within 350 km of Knoxville.

DSM → AVL 138 km from TYS Des Moines → Asheville USA · 26 destinations DSM → CHA 139 km from TYS Des Moines → Chattanooga USA · 16 destinations DSM → TRI 161 km from TYS Des Moines → Bristol, VA/Johnson City/Kingsport USA · 8 destinations DSM → GSP 190 km from TYS Des Moines → Greenville USA · 31 destinations DSM → ATL 244 km from TYS Des Moines → Atlanta USA · 246 destinations

Other flights from Des Moines (DSM)

Atlanta (ATL) Austin (AUS) Boston (BOS) Burbank (BUR) Charlotte (CLT) Chicago (ORD) Chicago (MDW) Dallas (DFW) All 35 destinations →

Other flights from Knoxville (TYS)

Atlanta (ATL) Austin (AUS) Baltimore (BWI) Baton Rouge (BTR) Bentonville (XNA) Boston (BOS) Charlotte (CLT) Chicago (MDW) All 40 destinations →